Evolution of SET-domain Protein Families in Fungi
Author Information
Author(s): Veerappan Chendhore, Avramova Zoya, Moriyama Etsuko N
Primary Institution: University of Nebraska-Lincoln
Hypothesis
Do the types and numbers of SET-domain genes in unicellular and multicellular fungi correlate with their biological complexity?
Conclusion
SET-domain genes in filamentous fungi reflect evolutionary events of gene deletion or the emergence of novel structures associated with multicellularity.
Supporting Evidence
- SET-domain genes are ancient and found in both unicellular and multicellular organisms.
- Distinct SET-domain gene families are associated with multicellular functions.
- Loss of certain SET-domain genes in yeasts suggests alternative gene-silencing mechanisms.
Takeaway
This study looks at how certain genes in fungi have changed as they evolved from single-celled to multicellular forms, showing that some genes are lost while new ones appear.
Methodology
Phylogenetic analysis of SET-domain genes across various fungal genomes.
Limitations
The study primarily focuses on Ascomycota and may not represent other fungal groups.
Digital Object Identifier (DOI)
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