Effects of Vitamin D on Oxidative Stress in Multiple Sclerosis
Author Information
Author(s): Lis Martyna, Niedziela Natalia, Adamczyk-Zostawa Jowita, Zalejska-Fiolka Jolanta, Szczygieł Jarosław, Sowa Agata, Świętek Agata, Adamczyk-Sowa Monika
Primary Institution: Medical University of Silesia
Hypothesis
Does vitamin D supplementation reduce oxidative stress in patients with relapsing–remitting multiple sclerosis?
Conclusion
Vitamin D doses used in the study were likely too low to significantly improve oxidative stress markers in patients with relapsing–remitting multiple sclerosis.
Supporting Evidence
- Vitamin D supplementation increased serum levels of 25(OH)D in both groups.
- Significant increases in oxidative stress markers were observed.
- Most participants had hypovitaminosis D before supplementation.
- After six months, a significant positive correlation was found between serum vitamin D and antioxidant markers.
Takeaway
This study looked at how vitamin D might help people with multiple sclerosis feel better by reducing stress in their bodies, but the doses used weren't strong enough to see big changes.
Methodology
The study compared two doses of vitamin D supplementation over six months in patients with relapsing–remitting multiple sclerosis, measuring various oxidative stress markers.
Potential Biases
Participants were on various disease-modifying therapies, which could influence the outcomes.
Limitations
The study had a small sample size and lacked a control group, which may affect the reliability of the results.
Participant Demographics
The study included 52 patients, with a median age of 47 years, and 63.46% were female.
Statistical Information
P-Value
p < 0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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