Effect of total parenteral nutrition on the duration of haemofilter circuit
2011
Impact of Total Parenteral Nutrition on Haemofilter Circuit Duration
Sample size: 121
publication
Evidence: moderate
Author Information
Author(s): Saha S, Shah P, Gibbs J, Collins J
Primary Institution: Broomfield Hospital, Chelmsford, UK
Hypothesis
Does total parenteral nutrition (TPN) infusion shorten the duration of haemofilter circuits during continuous renal replacement therapy (CRRT)?
Conclusion
Total parenteral nutrition significantly reduces the duration of the haemofilter circuit by about 7 hours.
Supporting Evidence
- The mean duration of haemofilter circuit was 24.51 hours without TPN and 17.22 hours on TPN.
- TPN use was significantly associated with a decrease in duration of filtration.
- The effect of TPN was found to be independent of the platelet count.
Takeaway
When patients receive total parenteral nutrition, the machines that filter their blood don't work as long, which can be a problem.
Methodology
A retrospective analysis of patient notes over 2 years comparing CRRT circuits with and without TPN.
Participant Demographics
Adult patients in a general ICU.
Statistical Information
P-Value
< 0.002
Confidence Interval
24.08 to 29.08 hours without TPN; 14.98 to 23.59 hours on TPN
Statistical Significance
p<0.002
Digital Object Identifier (DOI)
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