Role of NR2B-NMDARs in Memory and Synaptic Potentiation
Author Information
Author(s): Zhang Xue-Han, Wu Long-Jun, Gong Bo, Ren Ming, Li Bao-Ming, Zhuo Min
Primary Institution: Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University
Hypothesis
The functional role of NR2B-containing NMDA receptors in hippocampal LTP and memory depends on LTP-inducing and behavior-conditioning protocols.
Conclusion
NR2B-NMDARs are required for LTP induced by the spike-timing protocol, but not for LTP induced by the pairing or high-frequency stimulation protocols.
Supporting Evidence
- NR2B-NMDARs are required for LTP induced by spike-timing protocol.
- NR2B-NMDARs are not required for LTP induced by pairing or high-frequency stimulation protocols.
- Different conditioning strengths affect the role of NR2B-NMDARs in memory acquisition.
Takeaway
This study found that different ways of training animals affect how certain brain receptors help with memory and learning.
Methodology
The study used pharmacological antagonists to block NR2B-NMDARs and assessed their effects on LTP and fear memory in rats.
Participant Demographics
Sprague-Dawley rats (male, 200–220 g, 8–10 week old) and C57BL/6 mice (male, 6–8 week old).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website