Outcomes of Acute Kidney Injury in Children
Author Information
Author(s): Chisavu Flavia, Gafencu Mihai, Stroescu Ramona, Chisavu Lazar, Schiller Adalbert
Primary Institution: University of Medicine and Pharmacy ‘Victor Babes’ from Timisoara
Hypothesis
The study aims to evaluate the impact of acute kidney injury (AKI) duration on mortality and the risk of new-onset chronic kidney disease (CKD) in children.
Conclusion
The continuum of acute kidney injury expressed as acute kidney disease resulted in an increased risk of new-onset chronic kidney disease.
Supporting Evidence
- Children with acute kidney disease had the highest mortality rate at 16.42%.
- Transient AKI was present in 27.9% of patients, while persistent AKI was in 43%.
- New-onset CKD occurred in 4.05% of patients after an AKI episode.
Takeaway
This study found that children who have acute kidney injury for a longer time are more likely to develop serious kidney problems later on.
Methodology
A retrospective cohort study was conducted on 2346 children with AKI over a 9-year period.
Potential Biases
Potential bias due to the retrospective nature and exclusion of certain data points.
Limitations
The study is limited by its single-center and retrospective design, and the lack of urine output data.
Participant Demographics
Children aged 1 day to 18 years from a tertiary care hospital in Romania.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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