Doppler Measures of Dyssynchrony in Heart Failure Patients
Author Information
Author(s): Magnus Edner, Yong Kim, Knud Norregaard Hansen, Henrik Nissen, Geert Espersen, Karl La Rosee, Fikru Maru, Nick Freemantle, John Cleland, Peter Sogaard
Primary Institution: Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
Hypothesis
Patients with more left ventricular dyssynchrony pre-implantation will benefit more from cardiac resynchronization therapy (CRT).
Conclusion
Intra-ventricular dyssynchrony is prevalent in heart failure patients with wide QRS and depressed systolic function, and TSI is a reliable method to identify those likely to benefit from CRT.
Supporting Evidence
- 34% of patients had atrio-ventricular dyssynchrony.
- 60% of patients exhibited inter-ventricular mechanical delay.
- 85% of patients showed intra-ventricular dyssynchrony.
- Patients with cardiomyopathy were more likely to have significant dyssynchrony compared to those with ischemic heart disease.
Takeaway
This study looked at heart failure patients and found that many have a problem with their heart beating out of sync, which can be detected using special imaging techniques.
Methodology
Echocardiography including tissue Doppler imaging was used to assess dyssynchrony in 100 heart failure patients before CRT.
Potential Biases
Potential bias due to the observational nature of the study and the lack of outcome reporting.
Limitations
The study did not report on patient outcomes, and it was observational rather than a randomized controlled trial.
Participant Demographics
Patients were aged 67.1 years on average, with a mix of ischemic heart disease and cardiomyopathy.
Statistical Information
P-Value
p=0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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