Antibacterial and Anticancer Activities of South African Medicinal Plants
Author Information
Author(s): Bisi-Johnson Mary A, Obi Chikwelu L, Hattori Toshio, Oshima Yoshiteru, Li Shenwei, Kambizi Learnmore, Eloff Jacobus N, Vasaikar Sandeep D
Primary Institution: Walter Sisulu University
Hypothesis
This study investigates the cytotoxicity and antibacterial activities of selected South African medicinal plants.
Conclusion
The methanol extract of E. autumnalis showed significant cytotoxicity and antibacterial activity, raising concerns about its safety.
Supporting Evidence
- E. autumnalis had the least minimum inhibitory concentration (MIC) of 0.27 mg/mℓ.
- The methanol extract of E. autumnalis had an IC50 of 7.8 μg/mℓ, indicating strong cytotoxicity.
- A. arborescens and A. striatula showed insignificant or no cytotoxic effects.
Takeaway
Some plants that people think are safe can actually be harmful, and this study looked at how certain South African plants can fight bacteria and cancer.
Methodology
The study used broth micro-dilution methods to assess antibacterial activity and MTT assays for cytotoxicity on human cancer cell lines.
Limitations
The study did not assess long-term effects or safety of the plants in human subjects.
Digital Object Identifier (DOI)
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