Safety Evaluation of Maha Pigut Triphala in Rats
Author Information
Author(s): Intatham Supaporn, Taychaworaditsakul Weerakit, Khonsung Parirat, Chansakaow Sunee, Jaijoy Kanjana, Lertprasertsuke Nirush, Soonthornchareonnon Noppamas, Sireeratawong Seewaboon
Primary Institution: Faculty of Medicine, Chiang Mai University, Thailand
Hypothesis
The study aimed to investigate the acute and chronic oral toxicity of Maha Pigut Triphala in Sprague-Dawley rats.
Conclusion
Maha Pigut Triphala in the ratio of 2:1:3 does not cause acute or chronic oral toxicity in rats.
Supporting Evidence
- The study showed no abnormal behaviors or mortality in rats given Maha Pigut Triphala.
- Minor changes in body weight and organ weight were observed but were not clinically significant.
- Gross pathological and histopathological examinations revealed no abnormalities in internal organs.
Takeaway
Maha Pigut Triphala is safe for rats, meaning it doesn't make them sick even when given a lot over a long time.
Methodology
The study involved administering Maha Pigut Triphala to rats in both acute and chronic toxicity tests, observing for any adverse effects.
Participant Demographics
Sprague-Dawley rats, both male and female, weighing 180-200 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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