Centriole assembly and the role of Mps1: defensible or dispensable?
2011
The Role of Mps1 in Centriole Assembly
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Amanda N Pike, Harold A Fisk
Primary Institution: The Ohio State University
Hypothesis
Is Mps1 essential for centriole duplication?
Conclusion
Mps1 is not essential for centriole assembly but plays multiple roles in the process.
Supporting Evidence
- Mps1 is conserved from yeast to humans and regulates various cellular functions.
- Recent studies suggest Mps1 is dispensable for centriole assembly despite its involvement in the process.
- Overexpression of Mps1 can lead to extra centrioles, indicating its regulatory role.
Takeaway
Mps1 is a protein that helps build centrioles, which are important for cell division, but it's not always needed for this job.
Methodology
The review discusses various studies on Mps1's role in centriole assembly and its functions across different organisms.
Limitations
The review does not provide new experimental data but synthesizes existing literature.
Digital Object Identifier (DOI)
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