Perchloric acid-soluble proteins from goat liver inhibit chemical carcinogenesis of Syrian hamster cheek-pouch carcinoma
1999
Goat Liver Extract Reduces Tumors in Hamsters
publication
Evidence: moderate
Author Information
Author(s): Ghezzo F, Berta G N, Bussolati B, Bosio A, Corvetti G, Di Carlo F, Bussolati G, Guglielmone R, Bartorelli A
Primary Institution: University of Turin
Hypothesis
Can perchloric acid-soluble proteins from goat liver inhibit chemical carcinogenesis in Syrian hamsters?
Conclusion
The goat liver extract UK101 significantly reduced tumor development in Syrian hamsters compared to controls.
Supporting Evidence
- Less than 40% of animals treated with UK101 developed tumors compared to 100% of the controls.
- Immunocytochemical testing showed significantly fewer proliferating cells in UK101 animals than in controls.
- The effect of UK101 was reversed when dexamethasone was added.
Takeaway
Researchers found that a special goat liver extract helped prevent tumors in hamsters, showing it might help fight cancer.
Methodology
A blind study was conducted to test the effects of goat liver extract on tumor development in Syrian hamsters.
Participant Demographics
Syrian hamsters were used in the study.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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