K-SPMM: A Database of Murine Spermatogenic Promoters Modules & Motifs
Author Information
Author(s): Lu Yi, Adrian E Platts, G Charles Ostermeier, Stephen A Krawetz
Primary Institution: Wayne State University
Hypothesis
Understanding the regulatory processes that coordinate gene expression leading to male gamete development is challenging due to incomplete knowledge of regulatory elements.
Conclusion
K-SPMM provides a powerful tool for analyzing promoter regions and their components in male germ cells, aiding research on gene regulation.
Supporting Evidence
- K-SPMM contains data on 7,551 genes and 11,715 putative promoter regions.
- The system allows for flexible searches based on cell types and transcription factor families.
- Binding sites are identified through similarities to position weight matrices in JASPAR and TRANSFAC.
Takeaway
K-SPMM is like a big library that helps scientists find important parts of genes that help make sperm. It shows how these parts work together.
Methodology
The database was constructed using data from nine NCBI published cDNA libraries and includes promoter sequences and transcription factor binding sites.
Limitations
The databases are not fully complete regarding all transcription factors that direct spermatogenesis.
Participant Demographics
The study focuses on murine (mouse) spermatogenic cells.
Statistical Information
P-Value
0.98
Digital Object Identifier (DOI)
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