Study of Genes Related to Subarachnoid Hemorrhage
Author Information
Author(s): Kaushal Ritesh, Woo Daniel, Pal Prodipto, Haverbusch Mary, Xi Huifeng, Moomaw Charles, Sekar Padmini, Kissela Brett, Kleindorfer Dawn, Flaherty Matthew, Sauerbeck Laura, Chakraborty Ranajit, Broderick Joseph, Deka Ranjan
Primary Institution: University of Cincinnati
Hypothesis
Are variants in the APOE and ELN genes associated with subarachnoid hemorrhage?
Conclusion
This study suggests a role of the APOE gene in the etiology of aneurysmal SAH.
Supporting Evidence
- No individual SNP at the APOE locus was associated with SAH after correction for multiple comparisons.
- Haplotype analysis revealed significant association of the major haplotype in APOE with SAH.
- The study failed to confirm previous reports of ELN association with aneurysmal SAH.
Takeaway
The study looked at how certain genes might be linked to a type of brain bleed called subarachnoid hemorrhage, finding a connection with one gene but not the other.
Methodology
The study involved genotyping 12 SNPs on APOE and 10 SNPs on ELN in a case-control design with 107 SAH cases and 202 matched controls.
Potential Biases
Potential bias due to population substructure was addressed using genomic control methods.
Limitations
The study's findings are limited to Caucasian individuals and may not apply to other populations.
Participant Demographics
309 Caucasian individuals, including 107 SAH cases and 202 matched controls.
Statistical Information
P-Value
0.001
Statistical Significance
p = 0.001
Digital Object Identifier (DOI)
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