Genomic analysis of bacteriophage ε34 of Salmonella enterica serovar Anatum
2008
Genomic Analysis of Bacteriophage ε34 of Salmonella enterica
publication
Evidence: moderate
Author Information
Author(s): Villafane Robert, Zayas Milka, Gilcrease Eddie B, Kropinski Andrew M, Casjens Sherwood R
Primary Institution: Ponce School of Medicine
Hypothesis
What is the genomic sequence of Salmonella phage ε34 and how does it compare to other P22-like phages?
Conclusion
The genomic analysis of phage ε34 reveals its significant role in modifying the O-antigen serotype of Salmonella hosts through horizontal gene transfer.
Supporting Evidence
- Phage ε34 is a member of the P22 branch of lambdoid phages.
- The gtrABC gene cluster in ε34 is responsible for modifying the host's O antigen.
- Comparative analysis shows that temperate phages contribute significantly to the serotype of Salmonella.
Takeaway
This study looks at a virus that infects Salmonella bacteria and how it can change the bacteria's surface to help it survive better.
Methodology
The study involved sequencing the DNA of phage ε34 and comparing it to other known phages.
Digital Object Identifier (DOI)
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