Survey of Patient Selection in Stomach Cancer Trials
Author Information
Author(s): L.C. Ward, J.W.L. Fielding, J.A. Dunn, K.A. Kelly
Primary Institution: University of Birmingham
Hypothesis
How do selection criteria affect the recruitment of patients for randomized trials in stomach cancer?
Conclusion
The study found that many eligible patients were excluded from trials due to strict selection criteria, which may affect the applicability of trial results.
Supporting Evidence
- Only 51% of non-trial cases met the selection criteria for the trial.
- Trial patients showed no significant survival advantage over non-trial patients after 2 years.
- Selection criteria led to a high exclusion rate of eligible patients.
Takeaway
This study looked at how many stomach cancer patients could join a trial and found that many were left out because of strict rules.
Methodology
A registry survey was conducted to compare trial patients with non-trial patients based on eligibility criteria.
Potential Biases
Potential bias due to selection criteria that may favor younger or healthier patients.
Limitations
The study may not account for all confounding factors affecting patient selection and outcomes.
Participant Demographics
Patients aged 15-74 with operable gastric carcinoma.
Statistical Information
P-Value
0.0001
Confidence Interval
(11, 14)
Statistical Significance
p<0.05
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