Case Report of Necrobiotic Xanthogranuloma Associated with Multiple Myeloma
Author Information
Author(s): Inthasotti Siriluk, Wanitphakdeedecha Rungsima, Manonukul Jane
Primary Institution: Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Hypothesis
Is necrobiotic xanthogranuloma associated with asymptomatic multiple myeloma?
Conclusion
The patient was diagnosed with necrobiotic xanthogranuloma associated with asymptomatic multiple myeloma after a 7-year history of skin lesions.
Supporting Evidence
- Necrobiotic xanthogranuloma is a rare condition with approximately 100 cases reported worldwide.
- 80-90% of necrobiotic xanthogranuloma cases are associated with monoclonal gammopathy.
- The patient had multiple yellowish to reddish-brown nodules and plaques on her skin.
- Initial misdiagnosis included xanthelasma and granuloma annulare.
- Biopsies revealed features consistent with necrobiotic xanthogranuloma.
Takeaway
A woman had skin bumps for 7 years, which turned out to be linked to a type of blood cancer called multiple myeloma.
Methodology
The case involved multiple biopsies and investigations to diagnose necrobiotic xanthogranuloma and associated multiple myeloma.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
A 64-year-old woman.
Digital Object Identifier (DOI)
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