MMP-1 Expression and Breast Cancer Prognosis
Author Information
Author(s): Pia Boström, Mirva Söderström, Tero Vahlberg, Karl-Ove Söderström, Peter J. Roberts, Olli Carpén, Pirkko Hirsimäki
Primary Institution: University of Turku and Turku University Central Hospital
Hypothesis
MMP-1 expression in breast cancer cells and stromal cells correlates with traditional prognostic factors and patient survival.
Conclusion
MMP-1 expression in both tumor and stromal cells is associated with breast tumor progression and poor prognosis.
Supporting Evidence
- MMP-1 expression positively correlates with tumor grade.
- Higher MMP-1 levels in tumor cells are linked to poorer survival outcomes.
- MMP-1 expression varies significantly among different breast cancer subtypes.
Takeaway
This study found that a protein called MMP-1 can help predict how serious breast cancer might be, based on its levels in tumor cells.
Methodology
Immunohistochemical analysis of MMP-1 and other markers was performed on 125 breast cancer samples, followed by statistical analyses including survival analysis.
Limitations
The study was retrospective and lacked informed consent from individual patients.
Participant Demographics
125 female breast cancer patients, mean age 57.5 years, range 30-90 years.
Statistical Information
P-Value
p = 0.0171 for MMP-1 expression in tumor cells
Confidence Interval
95% CI for hazard ratios reported in survival analysis
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website