Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome
Author Information
Author(s): Zülfikar Memiş, Erdem Gürkaş, Atilla Özdemir, Bilgehan Atılgan, Muhammed Nur Ögün, Emrah Aytaç, Çetin Kürşad Akpınar, Eşref Akıl, Murat Çabalar, Ayça Özkul, Ümit Görgülü, Hasan Bayındır, Zaur Mehdiyev, Şennur Delibaş Katı, Recep Baydemir, Ahmet Yabalak, Ayşenur Önalan, Türkan Acar, Özlem Aykaç, Zehra Uysal Kocabaş, Serhan Yıldırım, Hasan Doğan, Mehmet Semih Arı, Mustafa Çetiner, Ferhat Balgetir, Fettah Eren, Alper Eren, Nazım Kızıldağ, Utku Cenikli, Aysel Büşra Şişman Bayar, Ebru Temel, Alihan Abdullah Akbaş, Emine Saygın Uysal, Hamza Gültekin, Cebrail Durmaz, Ulaş Sena Boncuk, Talip Asil, Sonu M. M. Bhaskar
Primary Institution: Haseki Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
Hypothesis
This study investigates the relationship between admission NLR, stroke severity, and 90-day outcomes in patients with anterior circulation large vessel occlusion undergoing early, successful revascularization.
Conclusion
Admission NLR is associated with stroke severity but does not independently predict clinical outcomes at 90 days in patients achieving early and successful revascularization.
Supporting Evidence
- Admission NLR correlated weakly but significantly with both baseline and 24 h NIHSS scores, reflecting stroke severity.
- High 24 h NIHSS scores and prolonged puncture-to-recanalization times were independent predictors of poor 90-day outcomes.
- 636 patients had good functional outcomes 3 months after acute ischemic stroke.
Takeaway
Doctors looked at a blood test called NLR to see if it could help predict how bad a stroke would be and how well people would recover, but it didn't help much for long-term recovery.
Methodology
A retrospective multicenter study was conducted with 1082 patients treated with mechanical thrombectomy for acute ischemic stroke, analyzing the relationship between admission NLR, NIHSS scores, and 90-day mRS outcomes using logistic regression.
Potential Biases
Potential confounding factors such as age and pre-stroke disability were minimized by excluding certain patients.
Limitations
The study only included patients with early and successful revascularization and did not analyze post-stroke inflammatory changes or delayed NLR measurements.
Participant Demographics
Of the 1082 patients, 545 (50.4%) were female and 537 (49.6%) were male, with a mean age of 65.1 years.
Statistical Information
P-Value
0.557
Confidence Interval
0.803–0.859
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website