Integrating Biosystem Models Using Waveform Relaxation
Author Information
Author(s): Li Linzhong, Seymour RobertM, Baigent Stephen
Primary Institution: Institute for Energy Technology (IFE)
Hypothesis
How can we systematically and efficiently integrate component models into larger composite models in systems biology?
Conclusion
The waveform relaxation method provides a flexible means to deal with multitime-scale computation and model heterogeneity in biological systems.
Supporting Evidence
- The waveform relaxation method allows for the integration of independently treated subsystems.
- Case studies demonstrate the method's efficiency in handling multiscale biological models.
- The method supports both deterministic and stochastic simulations.
Takeaway
This study shows a way to combine different biological models so they can work together better, like making a team of superheroes with different powers.
Methodology
The study adapts the waveform relaxation method for parallel computation of ordinary differential equations (ODEs) to integrate systems of linked submodels.
Limitations
The method may not be efficient for systems with very strong coupling among components over long-time intervals.
Digital Object Identifier (DOI)
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