Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
2008
Collagenase-3 Expression in Jaw Chondrosarcoma
Sample size: 11
publication
Evidence: moderate
Author Information
Author(s): Zyada Manal M, Shamaa Ali A
Primary Institution: Mansoura University, Egypt
Hypothesis
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
Conclusion
MMP-13 is expressed in the majority of chondrosarcoma of the jaws and may be related to tumor biological aggressiveness.
Supporting Evidence
- 72.8% of chondrosarcoma cases showed positive MMP-13 expression.
- Significant associations were found between MMP-13 expression and mitotic counts and necrosis.
- High-grade tumors had a significant difference in MMP-13 expression compared to low-grade tumors.
Takeaway
This study looked at a protein called MMP-13 in jaw tumors to see if it can help doctors understand how aggressive the tumors are.
Methodology
Archival tumor tissues from 11 patients were analyzed by immunohistochemistry for MMP-13 expression.
Limitations
The study had a small sample size.
Participant Demographics
Patients aged 14–68 years, with a mean age of 39.7; 7 males and 4 females.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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