Lead-Binding Proteins: A Review
2011
Lead-Binding Proteins: A Review
publication
Evidence: moderate
Author Information
Author(s): Harvey C. Gonick
Primary Institution: David Geffen School of Medicine at UCLA
Hypothesis
Whether the lead-binding proteins in every organ are identical or different remains to be determined.
Conclusion
Lead-binding proteins occur in many organs and appear to afford some protection against lead toxicity.
Supporting Evidence
- Lead-binding proteins are low molecular weight proteins that sequester lead in a nontoxic form.
- Delta-aminolevulinic acid dehydratase (ALAD) is a key lead-binding protein in erythrocytes.
- Lead-binding proteins are inducible and provide protection against lead toxicity.
Takeaway
Lead-binding proteins help keep lead in a safe form in our bodies, especially in organs like the kidneys and brain.
Methodology
The review discusses various studies on lead-binding proteins across different organs, focusing on their characteristics and effects.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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