Sensitization and Cross-Reactivity of Celery Allergen Api g 2
Author Information
Author(s): Gadermaier Gabriele, Hauser Michael, Egger Matthias, Ferrara Rosetta, Briza Peter, Souza Santos Keity, Zennaro Danila, Girbl Tamara, Zuidmeer-Jongejan Laurian, Mari Adriano, Ferreira Fatima
Primary Institution: Christian Doppler Laboratory for Allergy Diagnosis and Therapy, University of Salzburg, Salzburg, Austria
Hypothesis
To investigate the sensitization prevalence and cross-reactivity of Api g 2 from celery stalks in a Mediterranean population and in a mouse model.
Conclusion
Api g 2 is a significant allergen in the LTP-sensitized population, showing common epitopes with other lipid transfer proteins.
Supporting Evidence
- 25.6% of subjects showed IgE reactivity to Api g 2.
- 10 out of 32 patients reported symptoms after consuming celery stalks.
- Significant IgE cross-reactivity was observed between Api g 2, Art v 3, and Pru p 3.
Takeaway
This study found that many people are allergic to a protein in celery, which can also cause reactions to other foods like peaches and mugwort pollen.
Methodology
The study screened 786 subjects for IgE reactivity using an allergen microarray and evaluated clinical data from 32 selected patients.
Limitations
The study primarily focused on a Mediterranean population, which may limit the generalizability of the findings.
Participant Demographics
The study included 786 non-randomized allergic subjects from Italy.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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