The Role of LZTS3 in Colon Cancer
Author Information
Author(s): Ye Kui, Cao Huaxiang, Xu Zihao, Liu Peng, Jiang Xueying, Liu Qiancheng, Yang Hongquan, Huo Menghua, Wang Teng, Wang Jian
Primary Institution: Wuxi Second Geriatric Hospital
Hypothesis
LZTS3 has an oncogenic role in colorectal adenocarcinoma (COAD).
Conclusion
LZTS3 is highly expressed in COAD and is associated with poor clinical outcomes.
Supporting Evidence
- LZTS3 expression is significantly higher in COAD than in normal tissues.
- High LZTS3 levels correlate with advanced disease stages.
- LZTS3 is an independent prognostic marker for COAD.
- Patients with high LZTS3 expression have worse overall survival.
- LZTS3 expression is linked to immune cell distributions in COAD.
Takeaway
LZTS3 is a gene that can help doctors understand how serious colon cancer is and how to treat it better.
Methodology
The study analyzed mRNA expression levels and clinical data from COAD patients using TCGA datasets.
Limitations
The study is based on bioinformatic analyses and requires further validation in biological models.
Participant Demographics
The study included 483 COAD cases and 41 normal colorectal tissues.
Statistical Information
P-Value
p = 0.003
Confidence Interval
95% CI: 0.913-0.957
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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