Factors Influencing ALT Levels and Liver Fibrosis in MASLD
Author Information
Author(s): S Sato, Iino Chikara, Sasada Takafumi, Soma Go, Furusawa Keisuke, Yoshida Kenta, Sawada Kaori, Mikami Tatsuya, Fukuda Shinsaku, Nakaji Shigeyuki, Sakuraba Hirotake
Primary Institution: Hirosaki University Graduate School of Medicine
Hypothesis
This study aimed to investigate factors, including genetic polymorphisms, associated with elevated ALT levels and liver fibrosis in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD).
Conclusion
An individualized treatment approach is warranted for patients with MASLD due to the influence of various factors on its progression, including genetic factors and lifestyle diseases.
Supporting Evidence
- Male sex, younger age, and high triglyceride levels were significant risk factors for ALT levels >30 U/L.
- GG genotypes of PNPLA3 rs738409 and rs2896019 were significant risk factors for elevated ALT levels.
- The study included 228 patients diagnosed with MASLD.
Takeaway
This study found that being male, younger, having high triglycerides, and certain genetic factors can lead to higher liver enzyme levels in people with a specific liver disease.
Methodology
The study analyzed 228 participants diagnosed with MASLD from a health checkup project, measuring liver fat content and stiffness using FibroScan and assessing 13 SNPs related to NAFLD.
Limitations
The study used FibroScan instead of liver biopsy for diagnosis, which may not be as accurate, and the results may not be generalizable to other ethnicities.
Participant Demographics
Participants were adults aged 19–88 years, with a significant portion being male.
Statistical Information
P-Value
0.004 and 0.007 for SNPs
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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