EGF Receptor in Non-Small Cell Lung Cancer
Author Information
Author(s): H. Dazzi, P.S. Hasleton, N. Thatcher, D.M. Barnes, S. Wilkes, R. Swindell, R.A.M. Lawson
Primary Institution: Cancer Research Campaign, Department of Medical Oncology, Christie Hospital and Holt Radium Institute
Hypothesis
What is the relationship between EGF receptor status and the prognosis of non-small cell lung cancer?
Conclusion
The study found that EGF receptor status does not significantly aid in the diagnosis or prognosis of non-small cell lung cancer.
Supporting Evidence
- EGF-R was found in all tumor types studied.
- 55% of squamous cell carcinomas stained very strongly for EGF-R.
- 81% of well-differentiated tumors were very strongly positive for EGF-R.
Takeaway
This study looked at lung cancer and found that a protein called EGF receptor is present in many tumors, but it doesn't really help doctors predict how well patients will do.
Methodology
The study analyzed paraffin-embedded samples from 152 non-small cell lung cancer patients using immunohistochemistry to assess EGF-R expression.
Limitations
The study's findings did not reach statistical significance, and the interpretation of data is limited due to the presence of EGF-R in some normal cells.
Participant Demographics
117 male and 35 female patients with a median age of 59 (range 38-75 years).
Statistical Information
P-Value
P=0.0032
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