Axonal regeneration after optic nerve crush in Nogo-A/B/C knockout mice
2008
Axonal Regeneration in Nogo-A/B/C Knockout Mice
Sample size: 40
publication
Evidence: high
Author Information
Author(s): Su Ying, Wang Feng, Zhao Shi-guang, Pan Shang-ha, Liu Ping, Teng Yan, Cui Hao
Primary Institution: First Clinical College of Harbin Medical University
Hypothesis
Nogo genes inhibit axonal regeneration after optic nerve injury.
Conclusion
Knockout of Nogo genes accelerates axonal regeneration after optic nerve injury.
Supporting Evidence
- GAP-43 expression was significantly higher in the experimental group than in the control group.
- Axonal growth was significantly more active at every observed time point in the experimental group.
- Nogo genes play an inhibitive role in axonal regeneration after optic nerve injury.
Takeaway
This study shows that removing certain genes helps nerves grow back after being hurt.
Methodology
The study involved 20 Nogo-A/B/C knockout mice and 20 control mice, with optic nerve injury induced and subsequent analysis of axonal growth and gene expression.
Participant Demographics
Young adult mice, 8 to 12 weeks old.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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