AT1 Receptor Gene Polymorphisms and Postprandial Lipemia
Author Information
Author(s): B. Klop, T. M. van den Berg, A. P. Rietveld, J. Chaves, J. T. Real, J. F. Ascaso, R. Carmena, J. W. F. Elte, Manuel Castro Cabezas
Primary Institution: St. Franciscus Gasthuis, Rotterdam, The Netherlands
Hypothesis
The common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene affect postprandial lipemia.
Conclusion
The 1166-C allele of the AT1R gene is associated with increased postprandial lipemia.
Supporting Evidence
- Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele compared to homozygous carriers of the 1166-A allele.
- The frequency of the T-allele for the C573T gene polymorphisms was 65%.
- The C-allele for the A1166C gene polymorphisms showed a frequency of 60%.
- All polymorphisms were in Hardy–Weinberg equilibrium.
- Postprandial lipemia was similar for the different C573T gene polymorphisms.
Takeaway
Some people have a gene that makes their blood fat levels go up more after eating, which can be bad for their heart.
Methodology
Eighty-two subjects measured daytime capillary triglycerides, and postprandial lipemia was estimated as incremental area under the triglyceride curve.
Limitations
The study had a small number of homozygous carriers of the 1166-C allele.
Participant Demographics
The study included normocholesterolemic CAD patients and their first-degree relatives.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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