Failure Tolerance of Motif Structure in Biological Networks
Author Information
Author(s): Mirzasoleiman Baharan Jalili, Mahdi Jalili
Primary Institution: Sharif University of Technology
Hypothesis
How do random and systematic failures in the edges of biological networks influence their motif structure?
Conclusion
The study found that removing edges connected to high degree nodes has the most destructive effect on the motif structure of biological networks.
Supporting Evidence
- Removing edges connected to high degree nodes had the most catastrophic influence on the motif structure.
- Random failures can be as effective as systematic attacks in influencing motif structure.
- Systematic removal based on betweenness centrality had the least influence on motif significance.
Takeaway
This study looked at how breaking connections in biological networks affects their important patterns, called motifs. It found that breaking certain connections can really change how these patterns work.
Methodology
The study analyzed two biological networks using various strategies for edge removal and calculated the significance of network motifs.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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