Thymidylate Synthase Expression in Gastric Cancer Patients
Author Information
Author(s): Choi J-H, Lim H-Y, Nam D K, Kim H S, Cho D Y, Yi J W, Kim H C, Cho Y K, Kim M W, Joo H J, Lee K B, Kim K B
Primary Institution: Ajou University School of Medicine
Hypothesis
Does thymidylate synthase expression correlate with clinicopathologic characteristics and prognosis in gastric cancer patients treated with adjuvant chemotherapy?
Conclusion
High thymidylate synthase expression is linked to certain tumor characteristics but does not predict survival outcomes in gastric cancer patients treated with specific chemotherapy.
Supporting Evidence
- 65 patients had high thymidylate synthase expression, while 38 had low expression.
- High TS expression was associated with male gender and poorly differentiated histology.
- There were no significant differences in survival rates between high and low TS expression groups.
Takeaway
The study looked at a protein called thymidylate synthase in stomach cancer patients and found that while it is related to some tumor features, it doesn't help predict how long patients will live after treatment.
Methodology
Immunohistochemical staining was used to evaluate thymidylate synthase expression in tumor samples.
Limitations
Further studies are needed to evaluate other biological markers related to drug resistance.
Participant Demographics
103 locally advanced gastric cancer patients (stage IB–IV), with a mix of genders and tumor characteristics.
Statistical Information
P-Value
P = 0.002 for gender, P = 0.015 for histology, P = 0.027 for Lauren's classification, P = 0.548 for disease-free survival, P = 0.792 for overall survival.
Digital Object Identifier (DOI)
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