Mutations in Bcl10 are very rare in colorectal cancer
1999
Bcl10 Mutations in Colorectal Cancer
Sample size: 132
publication
Evidence: low
Author Information
Author(s): Stone J G, Rowan A J, Tomlinson I P M, Houlston R S
Primary Institution: Section of Cancer Genetics, Institute of Cancer Research
Hypothesis
Is Bcl10 frequently mutated in colorectal cancer?
Conclusion
Bcl10 is unlikely to be involved in the pathways of colorectal carcinogenesis.
Supporting Evidence
- Only one mutation was found in the colorectal cancer cell lines.
- No pathogenic mutations were detected in the tumours.
Takeaway
Scientists looked for changes in a gene called Bcl10 in people with colorectal cancer and found very few changes, suggesting it doesn't play a big role in this type of cancer.
Methodology
Analyzed 132 colorectal cancers and eight colorectal cancer cell lines for mutations in Bcl10.
Digital Object Identifier (DOI)
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