Using Serum Amyloid A and C Reactive Protein to Differentiate Between Exudates and Transudates
Author Information
Author(s): Alessandra M. Okino, Cristiani Bürger, Jefferson R. Cardoso, Edson L. Lavado, Paulo A. Lotufo, Ana Campa
Primary Institution: Universidade Estadual de Londrina
Hypothesis
Can serum amyloid A (SAA) be used effectively to distinguish between exudates and transudates in pleural and ascitic fluids?
Conclusion
Serum amyloid A is a valuable marker for differentiating between exudates and transudates.
Supporting Evidence
- SAA concentration in exudates was significantly higher than in transudates.
- There was a strong positive correlation between serum and exudate SAA concentration.
- SAA was found to be a better marker than CRP for distinguishing between exudates and transudates.
Takeaway
This study found that a protein called serum amyloid A can help doctors tell the difference between two types of fluid buildup in the body, which is important for treatment.
Methodology
SAA, CRP, and total protein were measured in pleural and ascitic effusions and corresponding serum samples from hospitalized patients.
Limitations
The study focused only on hospitalized patients and may not be generalizable to all populations.
Participant Demographics
Patients included 36 with exudates (27 pleural and 9 ascitic) and 12 with transudates (9 pleural and 3 ascitic).
Statistical Information
P-Value
< 0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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