Latexin and Neuropathic Pain
Author Information
Author(s): Kühlein Hilmar Nils, Tegeder Irmgard, Möser Christine, Lim Hee-Young, Häussler Annett, Spieth Katharina, Jennes Ingo, Marschalek Rolf, Beckhaus Tobias, Karas Michael, Fauth Markus, Ehnert Corina, Geisslinger Gerd, Niederberger Ellen
Primary Institution: Goethe-Universität Frankfurt am Main
Hypothesis
Neuropathic pain may arise from a dys-balance of activator/inhibitor or agonist/antagonist protein pairs.
Conclusion
The study suggests that carboxypeptidase A inhibition might be useful to reduce cold allodynia.
Supporting Evidence
- 55 significantly regulated proteins were detected after nerve injury.
- Latexin protein expression was reduced after nerve injury.
- Normalization of latexin expression reduced acetone-evoked nociceptive behavior.
Takeaway
When nerves are injured, a protein called latexin decreases, which can lead to pain. Fixing this problem might help reduce that pain.
Methodology
The study used a proteomic analysis with 2D-difference gel electrophoresis (DIGE) to assess protein regulations in the spinal cord after nerve injury.
Limitations
The study primarily focused on one model of neuropathic pain and may not generalize to all types of neuropathic pain.
Participant Demographics
Male Sprague Dawley rats and C57BL/6 mice were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website