Vitamin D and Breast Cancer Treatment
Author Information
Author(s): Ottaiano Alessandro, Facchini Bianca Arianna, Iacovino Marialucia, Santorsola Mariachiara, Facchini Sergio, Di Mauro Giordana, Toscano Enrica, Montopoli Monica, Di Mauro Annabella, Quagliariello Vincenzo, Maurea Nicola, Vanni Gianluca, Bignucolo Alessia, Montella Liliana, Materazzo Marco, Roselli Mario, Buonomo Oreste Claudio, Berretta Massimiliano
Primary Institution: Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”
Hypothesis
Does baseline vitamin D level affect the response to neoadjuvant chemotherapy in breast cancer patients?
Conclusion
Adequate vitamin D levels are associated with improved treatment response and progression-free survival in breast cancer patients undergoing neoadjuvant chemotherapy.
Supporting Evidence
- Vitamin D levels were assessed prior to chemotherapy.
- Six studies were included in the meta-analysis.
- Patients with adequate vitamin D levels had a 22% lower risk of non-response to treatment.
- Patients with sufficient vitamin D levels had a 35% lower risk of disease progression.
- Meta-analysis covered data from 722 patients regarding NACT response and 1033 patients for PFS.
- Statistical heterogeneity was evaluated with I2 statistics.
- Quality assessment was conducted using MINORS, NOS, and RoB2 scales.
Takeaway
Having enough vitamin D can help breast cancer patients respond better to treatment and live longer without the disease coming back.
Methodology
A systematic review and meta-analysis of studies assessing the impact of baseline vitamin D levels on treatment response and progression-free survival in breast cancer patients undergoing neoadjuvant chemotherapy.
Potential Biases
Potential biases related to data quality and completeness in retrospective studies.
Limitations
Most studies were retrospective, varied in vitamin D assessment methods, and lacked adjustment for seasonal variations in vitamin D levels.
Participant Demographics
Included patients aged over 18 with pathologically confirmed breast cancer, primarily stages I to III.
Statistical Information
P-Value
0.001
Confidence Interval
95% CI: 0.30–1.25
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website