Lactobacilli Strains Improve Protection Against Respiratory Infections
Author Information
Author(s): Albarracin Leonardo, Dentice Maidana Stefania, Fukuyama Kohtaro, Elean Mariano, Argañaraz Aybar Julio Nicolás, Suda Yoshihito, Nishiyama Keita, Kitazawa Haruki, Villena Julio
Primary Institution: Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), San Miguel de Tucumán, Argentina
Hypothesis
Can orally administered lactobacilli strains enhance resistance to respiratory superinfection?
Conclusion
The study found that specific lactobacilli strains can significantly improve resistance to secondary bacterial infections in the respiratory tract.
Supporting Evidence
- Infant mice treated with L. rhamnosus CRL1505 showed improved survival rates against secondary pneumococcal infections.
- Oral administration of lactobacilli enhanced the production of interferons in the respiratory tract.
- Lower levels of lung injury markers were observed in lactobacilli-treated mice compared to controls.
- Long-term protection against secondary infections was noted up to 20 days after treatment.
Takeaway
Giving certain good bacteria to baby mice helps them fight off bad germs that can make them sick after a cold.
Methodology
Infant mice were fed specific lactobacilli strains and then exposed to respiratory infections to assess their immune response and resistance.
Potential Biases
Potential bias in the selection of lactobacilli strains and the specific animal model used.
Limitations
The study primarily used infant mice, which may not fully represent responses in older populations or humans.
Participant Demographics
Infant BALB/c mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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