Gold and Silver Thiolate Complexes: A Review
Author Information
Author(s): Helen E. Howard-Lock
Primary Institution: McMaster University
Hypothesis
We postulate an equilibrium between polymeric, mononuclear and free ligand species for [AuLII]n.
Conclusion
The study concludes that the main components of GST in solution and solid are a mononuclear complex, a tetranuclear complex, and a polymeric complex.
Supporting Evidence
- The ESI-MS results show a tetrameric principal species in the 1:1 gold polymers.
- Biological tests indicated that S-GST had a greater inhibitory effect than R-GST.
- Mass spectral studies revealed that the main species in solution is a cyclic tetramer.
Takeaway
This study looks at different forms of gold and silver compounds that might help treat arthritis, showing that they can exist in various structures.
Methodology
The study involved reviewing crystal structures, mass spectra, and chiral HPLC data of various gold and silver thiolate complexes.
Limitations
The exact nature of the drug Myochrysine was poorly characterized, and the study faced challenges in crystallizing the compounds.
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