Should LSIL with ASC-H in cervical smears be an independent category?
Author Information
Author(s): Vinod B Shidham, Nidhi Kumar, Raj Narayan, Gregory L Brotzman
Primary Institution: Medical College of Wisconsin
Hypothesis
Is LSIL with ASC-H (LSIL-H) a distinct category in cervical smears?
Conclusion
LSIL-H overlaps with LSIL and ASC-H, but is distinct from HSIL, suggesting a management algorithm similar to ASC-H and HSIL.
Supporting Evidence
- LSIL-H accounted for 0.19% of all Pap tests in the study.
- 94% of LSIL-H cases were positive for high-risk HPV.
- LSIL-H had a higher positive predictive value for high-grade dysplasia compared to LSIL.
Takeaway
Some cervical smear results show low-grade lesions that might also have signs of high-grade lesions. This study looks at whether these should be treated as a separate category.
Methodology
The study analyzed cervical specimens over one year, comparing cytology results with biopsy outcomes.
Potential Biases
Variability in reporting practices among different laboratories may affect results.
Limitations
The cyto-histo correlation was only available in 40% of cases, and some specimens were not sent for surgical pathology.
Participant Demographics
Participants ranged in age from 16 to 65 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website