Stability-indicating spectrophotometric quantification of safinamide in the presence of its possible degradation product
2025
Measuring Safinamide and Its Degradation Product
publication
Evidence: high
Author Information
Author(s): Kamel Ebraam, El-Abassy Omar M
Primary Institution: Egyptian Russian University
Hypothesis
The study aims to develop reliable spectrophotometric methods for quantifying Safinamide and its degradation product.
Conclusion
The developed methodologies provide accurate and environmentally friendly ways to measure Safinamide and its degradation product.
Supporting Evidence
- The methods were validated for linearity within specific concentration ranges for both Safinamide and its degradation product.
- The study confirmed the structure of the degradation product using infrared and mass spectrometry.
- The proposed methods are environmentally friendly and cost-effective.
Takeaway
This study created new ways to measure a medicine called Safinamide and its breakdown product, which helps ensure the medicine is safe and effective.
Methodology
Two spectrophotometric methods were developed for the simultaneous estimation of Safinamide and its degradation product using various analytical techniques.
Digital Object Identifier (DOI)
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