Schwann Cell Proliferation and Survival Induced by Dilong through PI3K/Akt Signaling Mediated by IGF-I
2011
How Dilong Extract Helps Nerve Cells Grow
publication
Evidence: moderate
Author Information
Author(s): Chang Yung-Ming, Kuo Wu-Hsien, Lai Tung-Yuan, Shih Ying-Ting, Tsai Fuu-Jen, Tsai Chang-Hai, Shu Wen-Tong, Chen Ying-Yu, Chen Yueh-Sheng, Kuo Wei-Wen, Huang Chih-Yang
Primary Institution: China Medical University
Hypothesis
The study investigates the molecular mechanisms by which Dilong promotes neuron regeneration.
Conclusion
Dilong extract promotes the proliferation and survival of Schwann cells through the IGF-I signaling pathway.
Supporting Evidence
- Dilong extract activates the PI3K/Akt pathway, promoting cell survival.
- Treatment with Dilong extract increases the expression of cyclins involved in cell cycle progression.
- The study shows that IGF-I is crucial for Schwann cell proliferation and survival.
Takeaway
Dilong extract helps nerve cells grow and survive by activating certain proteins in the cells.
Methodology
The study used RSC96 cells treated with Dilong extract and analyzed cell viability, protein expression, and cell cycle progression.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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