Crystal structures of two different multi-component crystals consisting of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline and fumaric acid
2024
Crystal Structures of Two Multi-Component Crystals
publication
Evidence: moderate
Author Information
Author(s): Shibata Hiroki, Sakon Aya, Takata Noriyuki, Takiyama Hiroshi
Primary Institution: Chugai Pharmaceutical Co. Ltd.
Hypothesis
The study aims to synthesize and analyze the crystal structures of two different multi-component crystals consisting of papaverine and fumaric acid.
Conclusion
The study successfully identified two distinct crystal structures: a salt co-crystal and a salt-co-crystal intermediate.
Supporting Evidence
- Two different multi-component crystals were synthesized.
- One crystal was identified as a salt co-crystal and the other as a salt-co-crystal intermediate.
- Single-crystal X-ray analysis was performed to determine the structures.
Takeaway
Scientists made two types of crystals using a medicine and an acid, and they figured out how these crystals are built.
Methodology
Single-crystal X-ray structure analysis was used to determine the crystal structures of the synthesized compounds.
Digital Object Identifier (DOI)
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