Resveratrol as a Caloric Restriction Mimetic
Author Information
Author(s): Jamie L. Barger, Kayo Tsuyoshi, James M. Vann, Edward B. Arias, Jelai Wang, Timothy A. Hacker, Ying Wang, Daniel Raederstorff, Jason D. Morrow, Christiaan Leeuwenburgh, David B. Allison, Kurt W. Saupe, Gregory D. Cartee, Richard Weindruch, Tomas A. Prolla
Primary Institution: University of Wisconsin-Madison
Hypothesis
Does dietary resveratrol mimic the effects of caloric restriction on aging parameters in mice?
Conclusion
A low dose of dietary resveratrol can partially mimic caloric restriction and inhibit some aspects of aging in mice.
Supporting Evidence
- Resveratrol opposed 947 (92%) of age-related changes in gene expression.
- Both CR and resveratrol reduced age-related cardiac dysfunction.
- Resveratrol did not lower circulating IGF-1 levels unlike CR.
Takeaway
Giving mice a little bit of resveratrol, a compound found in grapes, helps them age more slowly, just like eating less food does.
Methodology
Mice were fed a control diet, a low dose of resveratrol, or a calorie-restricted diet, and their gene expression profiles were analyzed.
Limitations
The study did not evaluate the effects of resveratrol on average or maximum lifespan.
Participant Demographics
Male C57BL/6×C3H/He F1 hybrid mice, aged 14 to 30 months.
Statistical Information
P-Value
p≤0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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