3-[2-(1H-1,3-Benzodiazol-2-yl)ethyl]-1,3-oxazolidin-2-one
2011
Synthesis and Structure of a New Compound with Benzimidazole and Oxazolidinone
publication
Evidence: moderate
Author Information
Author(s): Brancatelli Giovanna, Nicoló Francesco, De Grazia Sara, Monforte Anna Maria, Chimirri Alba
Primary Institution: Università degli Studi di Messina
Hypothesis
The study aims to synthesize a compound that combines benzimidazole and oxazolidinone to achieve a synergistic effect.
Conclusion
The synthesized compound exhibits a staggered conformation and forms strong hydrogen bonds in the crystal structure.
Supporting Evidence
- The compound crystallizes in a centrosymmetric space group.
- A strong N—H⋯N hydrogen bond links the molecules into a chain.
- The dihedral angle between the oxazolone ring and the benzimidazole unit is 45.0°.
Takeaway
The researchers made a new chemical compound by combining two different structures, hoping it would work better together.
Methodology
The compound was synthesized using a one-pot reaction involving 2-(2-aminoethyl)-benzimidazole dihydrochloride and dibromoethane.
Digital Object Identifier (DOI)
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