Cancer and the FRA3B/FHIT fragile locus: it's a HIT
Author Information
Author(s): Kay Huebner, Croce C M
Primary Institution: Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA, USA
Conclusion
The study highlights the frequent loss of the FHIT gene in various cancers, suggesting its role as a tumor suppressor and potential target for gene therapy.
Supporting Evidence
- Fhit protein expression is lost or reduced in the majority of human cancers.
- Fhit knockout mice show increased susceptibility to spontaneous and induced tumors.
- Oral gene therapy using FHIT viruses prevents and reverses induced tumors in mice.
Takeaway
The FHIT gene is important for preventing cancer, and when it is damaged, it can lead to many types of cancer. Researchers are looking at ways to use this knowledge to help treat cancer.
Methodology
The review summarizes findings from various studies on FHIT gene alterations in different cancers, including immunohistochemical analysis and RT-PCR.
Limitations
The review is based on existing literature and may not include all recent studies or data.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website