Vitamin K Gene Variations in Mice
Author Information
Author(s): Song Ying, Vera Nicole, Kohn Michael H
Primary Institution: Rice University
Hypothesis
How do polymorphisms in the Vkorc1 gene affect vitamin K-dependent phenotypes in mouse strains?
Conclusion
Genetic variation in the Vkorc1 gene does not explain the substantial phenotypic variation in prothrombin time, bone mineral density, and bone mineral content among mouse subspecies.
Supporting Evidence
- Only four haplotypes were identified in commonly used laboratory strains of Mus musculus domesticus.
- No significant association was found between Vkorc1 haplotypes and prothrombin time, bone mineral density, or bone mineral content.
- Phenotypic variation in prothrombin time, bone mineral density, and bone mineral content appears to be dominated by genetic variation in other genes.
Takeaway
This study looked at a gene in mice that helps with blood clotting and bone health, but found that differences in this gene don't really explain why some mice have different blood and bone measurements.
Methodology
Sequenced the Vkorc1 gene in 40 mouse strains and analyzed haplotypes with respect to prothrombin time, bone mineral density, and bone mineral content.
Limitations
The study was limited by the small number of strains in some clades, which may affect the power of statistical tests.
Participant Demographics
40 mouse priority strains from various subspecies of Mus.
Statistical Information
P-Value
P = 0.389 for PT, P = 0.510 for BMD, P = 0.582 for BMC
Digital Object Identifier (DOI)
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