Modeling Gut Microbiome Metabolism in Infants
Author Information
Author(s): Shaaban Rola, Busi Susheel Bhanu, Wilmes Paul, Guéant Jean-Louis, Heinken Almut
Primary Institution: University of Lorraine, Nancy, France
Hypothesis
Cesarian section delivery alters not only the composition of the developing infant gut microbiome but also its metabolic capabilities.
Conclusion
Infants delivered through Cesarian section have reduced metabolic capabilities in their gut microbiomes compared to those delivered vaginally at early time points.
Supporting Evidence
- Infant gut microbiomes are enriched in B-vitamin biosynthesis compared to adult gut microbiomes.
- At the earliest stages, Cesarian section delivery gut microbiomes are depleted in metabolic capabilities.
- Microbiomes from infants delivered by Cesarian section had perturbed metabolic functions early in life.
Takeaway
Babies born by Cesarian section have fewer helpful bacteria in their tummies that help them digest food and stay healthy compared to babies born naturally.
Methodology
Metabolic modeling was performed for a cohort of 20 infants at four time points during the first year of life, using metagenomic data and personalized genome-scale community models.
Potential Biases
Potential biases may arise from the limited diversity in the cohort and the reliance on metagenomic data.
Limitations
The sample size is relatively small, limiting statistical power, and the study did not evaluate the impact of feeding mode due to a lack of data on formula-fed infants.
Participant Demographics
Cohort included 20 infants, with 11 vaginally delivered and 9 delivered through Cesarian section.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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