Angiotensin II and Tumor Blood Flow in Liver Metastases
Author Information
Author(s): Burke D, Davies M M, Zweit J, Flower M A, Ott R J, Dworkin M J, Glover C, McCready V R, Carnochan P, Allen-Mersh T G
Primary Institution: Imperial College School of Medicine, Chelsea and Westminster Hospital
Hypothesis
Can continuous angiotensin II infusion enhance blood flow to colorectal liver metastases?
Conclusion
Continuous angiotensin II infusion significantly increases blood flow to colorectal liver metastases compared to normal liver.
Supporting Evidence
- Prior to angiotensin II administration, tumor blood flow was generally greater than that of the liver.
- A significant increase in relative flow to tumor was seen in response to angiotensin II infusion in most cases.
- The effects of angiotensin II infusion appeared to be sustained throughout the infusion period.
Takeaway
This study found that giving a medicine called angiotensin II can help more blood reach cancer spots in the liver, which might help with treatment.
Methodology
Patients received a 45-minute regional infusion of angiotensin II, and blood flow was assessed using PET imaging.
Participant Demographics
Nine patients with unresectable hepatic disease were studied.
Statistical Information
P-Value
0.008
Confidence Interval
1.4–4.1
Statistical Significance
p=0.008
Digital Object Identifier (DOI)
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