Bromelia pinguin Extract Mitigates Glyphosate-Induced Toxicity in Human Cells
Author Information
Author(s): Muacevic Alexander, Adler John R, Masías-Ambriz Luis Omar, Caba-Flores Mario Daniel, Montes-Castro Nereida, García-Aguiar Israel, Ruiz-Ramos Ruben, Zenteno Edgar, Martínez-Valenzuela Carmen
Primary Institution: Universidad Autónoma de Occidente
Hypothesis
This research aimed to evaluate the protective effects of Bromelia pinguin extract on human peripheral blood mononuclear cells (PBMCs) exposed to glyphosate-based herbicides.
Conclusion
The extract of Bromelia pinguin can enhance cell viability and reduce the upregulation of inflammatory and apoptotic markers in human PBMCs exposed to glyphosate-based herbicides.
Supporting Evidence
- Glyphosate exposure reduced cell viability in a dose-dependent manner.
- Bromelia pinguin extract improved cell viability by up to 25% in glyphosate-treated groups.
- Western blot analysis showed reduced levels of inflammatory markers with Bromelia pinguin treatment.
Takeaway
Bromelia pinguin extract helps protect human cells from damage caused by glyphosate, a common herbicide, making it a potential natural remedy.
Methodology
PBMCs were isolated from healthy donors and exposed to glyphosate and Bromelia pinguin extract to assess cell viability and inflammatory markers.
Limitations
The study is in vitro, and results may not fully replicate in vivo conditions; only one glyphosate formulation was evaluated.
Participant Demographics
Three healthy male adult volunteers aged 20-23 years old, with no previous exposure to herbicides.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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