Gene Polymorphisms of Antioxidant Enzymes in Diabetes
Author Information
Author(s): Flekac Milan, Skrha Jan, Hilgertova Jirina, Lacinova Zdena, Jarolimkova Marcela
Primary Institution: 3rd Dept. of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Hypothesis
This study investigates the association between gene polymorphisms of selected antioxidant enzymes and vascular complications of diabetes mellitus.
Conclusion
The study shows that oxidative stress in diabetes can be worsened by reduced antioxidant defense due to specific gene polymorphisms.
Supporting Evidence
- Significant differences in allele and genotype distribution among T1DM, T2DM, and control persons were found in SOD1 and SOD2 genes.
- Serum SOD activity was significantly decreased in T1DM and T2DM subjects compared to control subjects.
- Better diabetes control was found in patients with CC than with TT genotype of SOD2 gene.
- Significantly different allele and genotype frequencies of SOD2 gene polymorphism were found among diabetic patients with macroangiopathy and those without it.
Takeaway
People with diabetes may have problems because their bodies can't fight off harmful substances as well due to their genes.
Methodology
The study examined 120 T1DM, 306 T2DM, and 140 control subjects, analyzing their genetic polymorphisms and serum SOD activity.
Potential Biases
Selection bias may affect the results due to the nature of the study design.
Limitations
The study has a relatively small sample size compared to larger epidemiological studies.
Participant Demographics
Participants included 120 Type 1 diabetes patients, 306 Type 2 diabetes patients, and 140 healthy controls.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI: 0.72, 0.79
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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