Remarks on the BOADICEA model of genetic susceptibility to breast and ovarian cancer
2005
Concerns About the BOADICEA Model for Breast Cancer Risk
Commentary
Author Information
Author(s): van Asperen C J, Jacobi C E, de Bock G H
Primary Institution: Leiden University Medical Center
Conclusion
The BOADICEA model for estimating breast cancer risk may be difficult for clinicians to use and understand.
Supporting Evidence
- The BOADICEA model predicts a high probability of BRCA1 mutations but gives a low breast cancer risk estimate.
- The 'Claus plus method' provides a more intuitive risk estimation for clinicians.
Takeaway
The BOADICEA model is supposed to help predict breast cancer risk, but it's confusing for doctors. A new method called 'Claus plus' might be easier to use.
Methodology
The authors extended the Claus tables into the 'Claus plus method' based on the Jonker model to simplify risk estimation.
Limitations
The BOADICEA model is not user-friendly for clinicians and requires further validation.
Digital Object Identifier (DOI)
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