How Prion Spreading Works in the Brain
Author Information
Author(s): Fornara Basile, Igel Angélique, Béringue Vincent, Martin Davy, Sibille Pierre, Pujo-Menjouet Laurent, Rezaei Human
Primary Institution: Université Paris-Saclay, INRAe, UVSQ, VIM, 78350 Jouy-en-Josas, France
Hypothesis
The dynamics of prion spreading is influenced by the interaction between tissue response and replication kinetics.
Conclusion
The study shows that prion propagation behaves as a complex system influenced by local tissue properties and strain-specific dynamics.
Supporting Evidence
- Prion sustainability is influenced by non-linear kinetics and tissue response.
- Strain-specific tissue tropisms in prion disease are explained.
- Axons guide long-distance extracellular prion spreading.
- Tissue mediates the co-propagation of prion strains.
Takeaway
Prions spread in the brain by changing how they replicate based on the surrounding tissue, which can affect how different strains of prions interact.
Methodology
The study used a stochastic reaction-diffusion model to simulate prion dynamics and tissue response.
Limitations
The model simplifies the tissue response to an all-or-nothing mechanism and does not account for cell diversity or other local physical factors.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website