Vitamin C vs Thiamine for Sepsis Treatment
Author Information
Author(s): Muacevic Alexander, Adler John R, Mishra Prashant K, Kumar Atit, Agrawal Sonali, Doneria Deepika, Singh Raghvendra
Primary Institution: Uttar Pradesh University of Medical Sciences, Etawah, IND
Hypothesis
This study aimed to investigate the outcomes associated with high-dose infusions of vitamin C and thiamine in septic patients.
Conclusion
Vitamin C infusion helps improve the SOFA score and CRP level in sepsis patients and reduces the duration of vasopressor therapy.
Supporting Evidence
- Vitamin C significantly improved SOFA scores compared to placebo.
- CRP levels were significantly lower in the vitamin C group than in the placebo group.
- The duration of vasopressor therapy was significantly lower in the vitamin C group.
- Thiamine reduced CRP levels compared to placebo.
- ARDS incidence was significantly lower in the vitamin C group.
Takeaway
This study looked at how vitamin C and thiamine help sick patients with sepsis. It found that vitamin C works better than thiamine.
Methodology
This prospective randomized comparative study involved 75 patients randomized into three groups receiving vitamin C, thiamine, or placebo for five days.
Limitations
The sample size may have been too small to detect minor differences, and the study duration might not have been sufficient to observe long-term outcomes.
Participant Demographics
Patients aged 18-65 with suspected infection and specific clinical criteria were included.
Statistical Information
P-Value
p=0.043 for SOFA score, p=0.0161 for CRP level, p=0.0276 for vasopressor therapy duration
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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