Determining Gabapentin in Capsules Using Spectrophotometry
Author Information
Author(s): Abdulrahman Sameer A. M. Basavaiah, Kanakapura Basavaiah
Primary Institution: Department of Chemistry, University of Mysore, Manasagangotri, Mysore, India
Hypothesis
The study aims to develop sensitive and selective spectrophotometric methods for determining gabapentin in pharmaceutical formulations.
Conclusion
The proposed methods for determining gabapentin are simple, rapid, and more sensitive than existing methods.
Supporting Evidence
- The methods showed no significant difference in accuracy and precision compared to reference methods.
- Recovery studies confirmed the validity of the proposed methods.
- The methods are free from the usual analytical complications like heating or extraction steps.
Takeaway
The researchers created two easy ways to measure gabapentin in medicine using special chemicals that change color.
Methodology
Two spectrophotometric methods were developed using picric acid and 2,4-dinitrophenol to form ion-pair complexes with gabapentin.
Potential Biases
Potential bias in the selection of reagents and methods compared to existing techniques.
Limitations
The methods may not be applicable to all formulations or other drugs.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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